“Midnight Muscle Cramps? Here’s What Your Body is Telling You”

Prairie Doc Perspective Week of October 19th, 2025
“Midnight Muscle Cramps? Here’s What Your Body is Telling You”
By Patti Berg-Poppe

You’re asleep when suddenly your calf tightens into a painful knot. You swing your legs over the side of the bed and stand up, trying to stretch the muscle and waiting for the cramp to release. It passes after a minute or two, but the soreness often lingers. These types of nighttime leg cramps are common and often harmless, but disruptive.

Studies suggest that up to 60% of adults experience leg cramps at night at some point in their lives. They become more common with age and can occur more frequently in people with certain medical conditions or those taking specific medications. 

The cause isn’t always clear, but several theories exist. One involves the gradual loss of motor neurons that occurs with aging. As nerve cells die off, the ones that remain may attempt to compensate by branching out to control more muscle fibers. This reorganization may make the system more prone to overexcitation, triggering cramps.

There is also a strong association between inactivity and muscle cramping. Many people spend long hours sitting or standing in place without moving through the full range of motion needed to keep leg muscles and tendons flexible. Over time, this can lead to muscle shortening, weakness, and poor circulation, all of which may increase the risk of cramping.

Daily activities that used to keep our muscles stretched and strong, such as squatting, kneeling, or walking on uneven terrain, are also less common in modern life. Without these movements, muscles like the hamstrings and those in our calves become less adaptable. The typical sleeping posture, with feet pointed down and ankles in plantarflexion, keeps the calf muscles in a shortened position for hours at a time. This posture may increase the likelihood of spontaneous nerve firing, especially during lighter stages of sleep.

Dehydration, electrolyte imbalances, and certain medications (such as diuretics) may also contribute to cramping. In some cases, leg cramps can be linked to medical conditions such as peripheral artery disease, diabetes or kidney disease.

Although painful, most nighttime leg cramps are not dangerous, and they can often be managed with simple changes. Stretching the calf muscles and hamstrings daily, especially before bed, may reduce the frequency and intensity of cramps. Staying physically active, including activities that strengthen the legs and promote circulation, can help maintain muscle function and flexibility. Walking, bicycling, heel raises and chair squats are practical options for many adults.

People who experience frequent cramps may benefit from adjusting their sleep posture. Using a pillow to keep the feet in a more neutral position, or avoiding heavy bedding that pushes the feet downward, can be helpful.

If cramps are severe, occur often or are associated with other symptoms, it’s worth talking with a health care provider to rule out underlying causes. In many cases, however, consistent movement, hydration and attention to daily habits can make a meaningful difference.

Patti Berg-Poppe is a physical therapist and professor at the University of South Dakota. Her work centers on helping people understand the connection between movement, health and maintaining independence and engagement throughout life. Follow The Prairie Doc® at www.prairiedoc.org, Facebook, Instagram, YouTube, and Tik Tok. Prairie Doc Programming includes On Call with the Prairie Doc®, a medical Q&A show (most Thursdays on SDPB at 7pm on YouTube and  streaming on Facebook), 2 podcasts, and a Radio program (on SDPB, Sundays at 6am and 1pm).